When the sync feature is completely disabled, the Sync option for all profiles will be greyed out (See the screenshot above). That means neither you can turn on sync nor you can adjust any type of sync settings. This will be applied automatically for all new profiles that you will create. Later, you can also enable data sync again anytime.

Disable sync for all Profiles in Edge using Registry Editor

You should backup Registry before doing any changes so that you restore it later if required. After that, follow these steps: Use the Search box or some other option to open Registry Editor. Now go to the Microsoft key. The path is here:

Under Microsoft key, there should be an Edge named Registry key. If it is not present, then create a new key, and then set its name to Edge. On the right-hand side of the Edge key, right-click on an empty area, select New, and use the DWORD (32-bit) Value. After you’ve created that value, rename it to SyncDisabled.

Double-click on SyncDisabled and a box will open. There, add 1 in its Value data field, and press OK.

Re-launch Microsoft Edge if it is already running. Now when you will access the Profiles section for a user profile, you will find that the Sync feature is not accessible. To re-enable data sync in Microsoft Edge, follow all the above steps, and add 0 in the Value data of SyncDisabled value, and press OK. Hope this will be helpful.